What are the best practices for optimizing SQL queries in Node.js applications using ORMs like Sequelize?

To optimize SQL queries in Node.js applications using Sequelize, start by analyzing query performance with tools like Sequelize's logging function or a database profiler. You can optimize queries by limiting returned data with selective `find` and `select` statements. Also, use indexing strategically to speed up searches on frequently queried columns.

I'd suggest that you do your best to avoid N+1 query problems by eager loading associated data where appropriate. Regularly review and refactor queries for efficiency, and consider caching frequently accessed data. Lastly, ensure your database schema and Sequelize models are well-optimized and align with your query patterns.